Monday, February 03, 2020

Why HIV drugs for common cold?

A paper, "Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag", was published on bioRxiv by researchers at Indian Institute of Technology (IIT) Delhi and Acharya Narendra Dev College, University of Delhi. "bioRxiv (pronounced 'bio-archive') is a free online archive and distribution service for unpublished preprints in the life sciences." "Articles are not peer reviewed, edited or typeset before being posted online." The paper was quickly retracted after criticism from scientists abroad. "Out of 4 inserts they identify between nCov and SARS, 2 are found in bat coronavirus. Of the remaining two, only one is most similar to HIV, and is so short (6AA) that the similarity is not higher than chance given database," tweeted Silvana Konerman. Speculation linking the 2019-nCoV to a biological weapons research laboratory in Wuhan has been dismissed by China, and was rubbished as conspiracy theory by Justin Ling. "A team led by Shi Zheng-Li, a coronavirus specialist at the Wuhan Institute of Virology, reported on 23 January on bioRxiv that 2019-CoV's sequence was 96.2% similar to a bat virus and had 79.5% similarity to the coronavirus that causes severe acute respiratory syndrome (SARS), a disease whose initial outbreak was also in China more than 15 years ago," wrote Jon Cohen. So, the similarities with the HIV genome is rubbish? Science keeps evolving as new observations lead to greater understanding of how nature works. What was dismissed as junk DNA in the past is now thought to have vital function in holding the integrity of the nucleus together. Coronaviruses cause common colds in humans and are RNA viruses which "spread through the air and are responsible for 10-30 percent of colds worldwide", said an article in the American Society for Microbiology. We do not prescribe anything stronger than hot chicken soup for the ordinary common cold, so why did the doctors at Rajavithi Hospital in Bangkok decide to treat a patient diagnosed with 2019-nCoV with "large doses of the flu drug oseltamivir combined with HIV drugs lopinavir and ritonavir". From testing positive for 10 days, a 70-year-old Chinese woman became negative in 48 hours. "A randomized controlled clinical trial is now underway in China to test anti-HIV drugs' efficacy". US airlines have suspended flights to China and foreigners who have been to China in the last 14 days are banned from entering the US. Don't worry say some. Common influenza kills 650,000 people worldwide every year. An Ebola outbreak has been going on since August 2018 in the Democratic Republic of Congo and neighboring countries but flights have not been stopped to any of these countries. Anti-HIV drugs are not used in ebola or for dengue fever which causes 390 million infections worldwide every year and has a 2-5% mortality rate. Why did Chinese President Xi Jinping call it a "devil virus" and why are Chinese police forcibly confining people indoors by chaining their doors from the outside? Drastic measures for something as harmless as common cold. Isn't it?

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